P2x7 Receptor: an Emerging Target in Cns Diseases 6 7
نویسندگان
چکیده
Published: Trends Pharmacol Sci. 2014 Oct;35(10):537-547. doi: 1 10.1016/j.tips.2014.08.002. 2 3 Trends in Pharmacological Science – accepted version 4 5 P2X7 receptor: an emerging target in CNS diseases 6 7 by Beata Sperlagh and Peter Illes 8 9 Department of Pharmacology, Institute of Experimental Medicine, Hungarian 10 Academy of Sciences, H-1450 Budapest, Hungary and Rudolf-Boehm-Institute 11 of Pharmacology and Toxicology, University of Leipzig, D-04107 Leipzig, 12 Germany 13 14 Corresponding author: Beáta Sperlágh 15 Department of Pharmacology, Institute of 16 Experimental Medicine, Hungarian Academy of 17 Sciences, H-1083 Budapest, Szigony u. 43., Hungary 18
منابع مشابه
P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation
P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...
متن کاملRecent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction. Emerging data has generated scientific interest and excitement around targeting the P2X7 ion channel as a potential drug target for CNS disorders. Over the past years, a wealth of data has been published on CNS P2X7 biology, in...
متن کاملThe P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis.
BACKGROUND Sepsis is associated with high mortality rates in intensive care units worldwide and represents a systemic inflammatory response to infection. P2X7 is an ionotropic purine receptor with known proinflammatory activity. Here, we investigated the role of the P2X7 receptor in sepsis induced by cecal ligation and puncture (CLP). METHODS Wild-type (WT) and P2X7KO (P2X7 null) mice were su...
متن کاملThe P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation. As such, P2X7 plays important roles in various inflammatory, immune, neurologic and musculoskeletal disorders. This review focuses on the ...
متن کاملP2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis
Tuberculosis (TB) remains a serious public health problem despite the great scientific advances in the recent decades. We have previously shown that aggressive forms of TB caused by hypervirulent strains of Mycobacterium tuberculosis and Mycobacterium bovis are attenuated in mice lacking the P2X7 receptor, an ion channel activated by extracellular ATP. Therefore, P2X7 receptor is a potential ta...
متن کامل